ABSTRACT
Kalri and Haleji lakes of Sindh region, Pakistan, are the important and valuable sources of water supply for drinking and irrigation purposes. A study was done to determine the concentration of pollutants [metal ions] in water and in different organs of fish, Labeo rohita by atomic absorption spectrophotometry. The concentration of metal ions [in water] was higher during the months of March to July. The highest peak for lead was found in Kalri and Haleji lakes which were followed by iron, chromium and zinc. Ions such as cadmium and manganese were found in least concentration. Bioaccumulation of metal ions in different organs of fish Labeo rohita, was found highest in liver while minimum concentration was found in adipose tissues. Generally two peaks were observed i.e., one in April to August and the other in November. It was found that there is higher amount of metal ions in Haleji lake water and fish organs. Therefore, supply of drinking water has been stopped from Haleji lake, possibly due to hepatotoxic and nephrotoxic effects